Modification of Hypoglycaemia with Hexamethonium Bromide

The hemodynamic effects of hexamethonium bromide in the dog, with special reference to splanchnic pooling.

Regulation of blood pressure levels by hexamethonium bromide and mechanical devices.

Probably the first studies of the pharmacology of quaternary ammonium compounds were made by Crum-Brown and Fraser in 1868. Burn and Dale (1915) found that, unlike nicotine, tetraethyl-ammonium chloride blocked autonomic ganglia without noticeable initial stimulation. Barlow and Ing (1948a and b), Paton and Zaimis (1948a and b), and Balaban et al. (1949) studied the properties of some chemical ...

Effects of TEAC and hexamethonium bromide on the intestinal movements of dog.

It is well known that the action of a drug on the intestinal movements in a particular species of animal depends on its functional autonomic innervation. In the present studies T EAC and Ca have been found to increase the rhythmic movements of the adult mongrel dog's intestine (in situ). The gut was subjected to vigourous circular contracractions but without the propulsive motility. These actio...

The treatment of hypertension with hexamethonium.

Hexamethonium by subcutaneous injection in doses of 10 to 75 mg. of the ion every 8 or 12 hours produced significant reductions of arterial pressure and symptomatic improvement in a high percentage of patients with benign or malignant hypertension. Methods for preventing tolerance and undesirable side effects are presented, and the advantages as well as the limitations of hexamethonium therapy ...

Inotropic action of hexamethonium.

The positive inotropic action of hexainethoniuin in hypodynamic and freshly prepared papillary muscles of the cat and the hypodynamic heart-lung preparation of the dog has been demonstrated. Within certain limits, there exists a proportionality between the concentration of hexamethonium and the magnitude of the inotropic response. In both preparations results have been obtained which indicate t...